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Beclomethasone acts topically and the absorption from the nasal mucous membrane is slight. Thus it acts in the superficial layers of the tissue, and with the recommended dosage, it is devoid of systemic effects.
Beclomethasone dipropionate is absorbed from the nasal mucosa. Part of the nasally administered dose of beclomethasone can pass the nose with inhaled air and retains in pharynx where it may be swallowed. This fraction undergoes a rapid first-pass in the liver to inactive metabolites. The drug that is absorbed from the nasal mucosa avoids this metabolism but is ultimately metabolized in the liver. Beclomethasone dipropionate is metabolized to beclomethasone monopropionate and free beclomethasone and metabolites are mainly excreted in the faeces.
